E. coli Pathway: peptidoglycan biosynthesis

Locations of Mapped Genes:

Genetic Regulation Schematic:

Synonyms: pepglycan

Superclasses: Murein sacculus

Comment: The three-layered coat of the gram-negative cell consists of an inner membrane, a peptidoglycan or murein layer and an outer membrane layer. Peptidoglycan is a cross-linked network of chains of subunits composed of two sugars and four amino acids. The sugars are arranged in chains and the amino acids provide the cross- linking between the glycan chains. The linear strand is composed of alternating subunits of N-acetylglucosamine and N-acetylmuramic acid. The amino acids in the side chain are L-alanine, D-glutamate, meso-diaminopimelic acid and D-alanine. Synthesis of peptidoglycan is a complex two-part process. The first part, assembly of the disaccharide-peptide monomer unit is shown here. Polymerization and binding of the monomer unit, the second part of the process, is not represented as it is currently beyond the scope of EcoCyc. [ 1 , 2 ]

Superpathways: peptidoglycan and lipid A precursor biosynthesis , KDO2-lipid A and peptidoglycan biosynthesis

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Please cite EcoCyc as Nucleic Acids Res. 28(1):56 2000 in publications resulting from its use.