E. coli Pathway: isopentenyl diphosphate biosynthesis -- mevalonate-independent

Locations of Mapped Genes:

Synonyms: nonmevalonate isopentenyl diphosphate biosynthesis

Superclasses: Cofactors, prosthetic groups, electron carriers

Comment: Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis. E. coli utilizes a mevalonate-independent pathway for synthesis of IPP. The pathway and its mechanics are still under investigation; the first four reactions are known. In the initial step 1-deoxy-D-xylulose 5-phosphate (DXP) is formed by condensation of pyruvate and glyceraldehyde 3-phosphate. In the second step DXP is rearranged and reduced in a single reaction yielding 2-C-methyl-D-erythritol 4-phosphate (MEP). In the third reaction MEP is converted into 4-diphosphocytidyl-2-C-methylerythritol, which is subsequently phosphorylated at the 2 position hydroxy group yielding 4-diphosphocytidyl-2C-methylerythritol 2-phosphate. This product is then converted into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate. The subsequent reaction(s) necessary to complete the pathway are not yet known. [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]

Citations: [ 9 , 10 , 11 ]


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Please cite EcoCyc as Nucleic Acids Res. 28(1):56 2000 in publications resulting from its use.