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ENTRY       EC 5.4.2.2
NAME        Phosphoglucomutase
            Glucose phosphomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     alpha-D-Glucose 1,6-phosphomutase
REACTION    alpha-D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate;
            alpha-D-Hexose 1-phosphate = alpha-D-Hexose 6-phosphate;
            alpha-D-Ribose 1-phosphate = alpha-D-Ribose 5-phosphate
SUBSTRATE   alpha-D-Glucose 1-phosphate
            alpha-D-Hexose 1-phosphate
            alpha-D-Ribose 1-phosphate
PRODUCT     alpha-D-Glucose 6-phosphate
            alpha-D-Hexose 6-phosphate
            alpha-D-Ribose 5-phosphate
COFACTOR    alpha-D-Glucose 1,6-bisphosphate
COMMENT     Maximum activity is only obtained in the presence of alpha-D-
            glucose 1,6-bisphosphate. This bisphosphate is an intermediate
            in the reaction, being formed by transfer of a phosphate residue
            from the enzyme to the substrate, but the dissociation of
            bisphosphate from the enzyme complex is much slower than the
            overall isomerization. The enzyme also, more slowly, catalyses
            the interconversion of 1-phosphate and 6-phosphate isomers of
            many other alpha-D-hexoses, and the interconversion of alpha-D-
            ribose 1-phosphate and 5-phosphate. Formerly EC 2.7.5.1.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00521  Streptomycin biosynthesis
            PATH: MAP00522  Erythromycin biosynthesis
            PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b0688(pgm) b3176(glmM)
            ECE: Z0837(pgm)
            ECS: ECs0719
            YPE: YPO2686(pgm)
            VCH: VC2095
            NME: NMB0790
            NMA: NMA1001(pgm)
            MLO: mll3879 mlr7590
            SME: SMb21081(manB) SMc03925(pgm)
            ATU: AGR_L_1564
            CCR: CC0085 CC0117
            BSU: BG12704(glmM)
            BHA: BH0267
            LLA: L35068(femD)
            SPY: SPy1038
            SPN: SP1559
            SAU: SA1965(glmM(femD))
            SAV: SAV2148(glmM)
            CAC: CAC0484
            MTU: Rv3068c(pgmA)
            MTC: MT3153
            CTR: CT815
            CMU: TC0202
            CPN: CPn0967
            CPA: CP0893
            CPJ: pgm
            BBU: BB0004(femD)
            TPA: TP0413
            SYN: sll0726(pgm)
            SCE: YKL127W(PGM1) YMR105C(PGM2)
            SPO: SPBC32F12.10(spbc32f12.10)
            ATH: At1g23190(T26J12.5) At1g70730(F5A18.9)
            CEL: R05F9.6
            DME: CG5165
            MMU: 97564(Pgm1) 97565(Pgm2)
            HSA: 5236(PGM1) 5237(PGM2) 5238(PGM3)
DISEASE     MIM: 171900  Phosphoglucomutase-1
MOTIF       PS: PS00710  [GSA]-[LIVMF]-x-[LIVM]-[ST]-[PGA]-S-H-[NIC]-P
STRUCTURES  PDB: 1JDY  1LXT  1VKL  3PMG  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.2
            ExPASy - ENZYME nomenclature database: 5.4.2.2
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.2
            BRENDA, the Enzyme Database: 5.4.2.2
            SCOP (Structural Classification of Proteins): 5.4.2.2
///

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